Melrose is a city located in the Greater Boston metropolitan area in Middlesex County, Massachusetts. Its population as per the 2010 United States Census is 26,983. It is a suburb located approximately seven miles north of Boston and is situated in the center of the triangle created by Interstates 93, 95 and US Route 1.The land that comprises Melrose was first settled in 1628 and was once part of Charlestown and then Malden. It became the Town of Melrose in 1850 and then the City of Melrose in 1900.